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Learn about its uses, side effects, interactions, pictures, warnings and user ratings from WebMD, the trusted source of medical ...Stimulants and irritability. Emotion dysregulation (irritability) is very common in children with ADHD. It is reported up to 25-45%. 6 While amphetamine-derived psychostimulants increase irritability, methylphenidate (MPH) derivatives significantly decrease the risk of irritability in comparison to placebo. 7 However, head-to-head comparison trials between methylphenidate and amphetamine ...Key takeaways: Adderall dosage for both children and adults starts at a lower dose, usually 2.5 mg once daily for children and 5 mg once or twice daily for adults. Adderall XR dosage for children often starts at 10 mg daily and dosage for adults usually starts at 20 mg daily. 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